S-Adenosyl methionine (SAM-e)

Max points: 5 Type: Podcast

This episode explores SAMe (S-adenosylmethionine), a natural compound with promising benefits for mood disorders. The hosts explain how it works in neurotransmitter production, review clinical studies comparing SAMe with antidepressants, discuss dosage, side effects, costs, and highlight when it may be a safe, effective treatment option.

Channel: Beautiful Minds Wellness Duration: 0:39:26

Questions

1. What key safety caution did the hosts highlight for certain patients considering SAMe?

Frequent permanent hair loss Potential for mania/hypomania in bipolar disorder Universal risk of kidney failure Commonly documented serotonin syndrome with all SSRIs

2. What total daily dosing range do the hosts commonly suggest many adults may land on with SAMe (divided doses)?

50–100 mg/day 800–1600 mg/day 5–10 mg/day 5000–10000 IU/day

3. Which neurotransmitter synthesis is mentioned as influenced by SAMe's methyl-donor action?

Endorphins Histamine only Serotonin GABA only

4. What does SAMe stand for, as discussed in the episode?

S-adenosyl-melatonin S-adenosylmethionine Serine–aspartate methyl ether Sarcosine-methyl-ester

5. Which biochemical process is emphasized as central to SAMe's mental health effects?

Transmethylation Glycolysis Beta-oxidation Phosphorylation

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